Elegant blouse, nice skirt or even T-shirt which you buy from famous designer is not complete yet without this collection: Clarks Women?s Desert Trek Boot. The Clarks Women?s Desert Trek Boot is the newest shoes product from us. It is designed to make your looking more amazing.
This classic Clarks boot has been around for nearly 30 years and is recognized by its signature center stitched seam. The Clarks Originals Desert Trek Women?s is set in suede full grain leather. This women?s boot has that classic Clarks comfort, with a cushioned foot bed that maintains heel stability. The roomy toe box of this Clarks Originals shoe allows you to spread your toes naturally. Finished with a genuine plantation crepe outsole for excellent shock absorption the Clarks Originals Desert Trek supports natural walking motion and foot health and gives you timeless style as well.Enjoy the classic good looks of Clarks Originals? Desert Trek oxford. It features a soft, nubuck upper for casual style, but you?ll be most impressed with the comfort of its thickly padded heel and springy crepe outsole.
Clarks Women?s Desert Trek Boot is made from high quality material. It will not make sencitive effect to your skin. Clarks Women?s Desert Trek Boot???s indentation is designed well and attach to the skin of your foot comfortly.
Besides that, the Clarks Women?s Desert Trek Boot???s material of the bottom design is anti-slip. Feel better to run in the floor. Step freely and make sure that every step of you is your best confidence. Make others stunned with Clarks Women?s Desert Trek Boot. Best Design of The Year.
Non-marking outsole with Wave Siping
Clarks Women?s Desert Trek Boot rated by user!
Talking about the design, Clarks Women?s Desert Trek Boot serve you best design of this year. Clarks Women?s Desert Trek Boot is created by the trusted designer. They know well about our top trend design today.
Good news! In the end of the year, get best deal from us. Bring Clarks Women?s Desert Trek Boot to your shoe rack with good deal price. Do not miss this good opportunity. Complete your shoe collection with Clarks Women?s Desert Trek Boot.
FILE - In this April 28, 2012 file photo, Lindsay Lohan attends the White House Correspondents' Association Dinner in Washington. A law enforcement official says a 25-year-old man got into an argument with Lohan, Sunday, Sept. 30, 2012, in her New York City hotel room over photos on a cellphone and she was physically grabbed or thrown. Authorities confirm that Christian LaBella of Valley Village, Calif., was taken into custody around 6 a.m. He faces a misdemeanor assault charge. (AP Photo/Haraz N. Ghanbari, File)
FILE - In this April 28, 2012 file photo, Lindsay Lohan attends the White House Correspondents' Association Dinner in Washington. A law enforcement official says a 25-year-old man got into an argument with Lohan, Sunday, Sept. 30, 2012, in her New York City hotel room over photos on a cellphone and she was physically grabbed or thrown. Authorities confirm that Christian LaBella of Valley Village, Calif., was taken into custody around 6 a.m. He faces a misdemeanor assault charge. (AP Photo/Haraz N. Ghanbari, File)
FILE - In this April 28, 2012 file photo, Lindsay Lohan attends the White House Correspondents' Association Dinner in Washington. A law enforcement official says a 25-year-old man got into an argument with Lohan, Sunday, Sept. 30, 2012, in her New York City hotel room over photos on a cellphone and she was physically grabbed or thrown. Authorities confirm that Christian LaBella of Valley Village, Calif., was taken into custody around 6 a.m. He faces a misdemeanor assault charge. (AP Photo/Haraz N. Ghanbari, File)
NEW YORK (AP) ? A 25-year-old man initially arrested Sunday on an assault charge after Lindsay Lohan claimed he grabbed her in her New York hotel room in an argument over cellphone images was freed hours later and his arrest voided when the charge could not be substantiated, law enforcement officials said.
Instead, Christian LaBella of Valley Village, Calif., and Lohan filed harassment complaints with police against each other after they were interviewed by police about their run-in, law enforcement officials said.
Afterward, Lohan publicist Steve Honig expressed outrage that police did not charge LaBella.
"We think it's both distressing and outrageous," he said in a telephone interview. "Lindsey was assaulted and there needs to be a consequence for that."
LaBella could not be reached for comment.
LaBella was taken into custody about 6 a.m. after a 911 call came from the swank W Hotel in Manhattan's Union Square where Lohan apparently pulled the fire alarm, the two officials said. The officials were not authorized to speak publicly and spoke to The Associated Press on condition of anonymity.
A former congressional aide, LaBella was arrested on a misdemeanor assault charge but released later Sunday. The charge could not be substantiated so the arrest will be voided, the officials said.
The paperwork was being completed on cross-harassment complaints, which are considered a violation, and no other legal action would be taken, the officials said.
Lohan and LaBella met hours earlier at a night club, though it was unclear whether they previously knew each other, the officials said. They went back to her room, when she noticed the cellphone photos of her on his phone and grabbed the device, the officials said.
She claimed LaBella grabbed her and threw her, but later he said she had forcefully taken his phone, the officials said. Lohan was injured but not hospitalized, Honig said in a statement.
"Lindsay has spoken with police and is fully cooperating with the investigation," he said after LaBella's arrest.
This is Lohan's second run-in with law enforcement in as many weeks in New York City. The 26-year-old was accused last week of clipping a pedestrian with her car outside a nightclub and driving away. She was given a ticket and was scheduled to appear in court Oct. 23. Honig has said he expects those allegations to be proven false.
The actress was also involved in a car accident in California this summer that sent her and an assistant to a hospital, but didn't result in serious injuries for anyone. The accident remains under investigation.
In May, she was cleared of allegations that she struck a Hollywood nightclub manager with her car.
Lohan remains on informal probation for taking a necklace from a jewelry store without permission last year. That means she doesn't have to check in with a judge or probation officer but could face a jail term if arrested again.
Lohan recently filmed "The Canyons," an indie film written by "Less Than Zero" and "American Psycho" author Bret Easton Ellis.
Steve Tomaszewski, a spokesman for Illinois Rep. John Shimkus, confirmed Sunday afternoon that LaBella has worked for the congressman in his Washington office. Tomaszewski said no one from the Republican's office had been contacted by LaBella.
Philly will try to keep Vick upright, but N.Y. must contain McCoy, among others
ANALYSIS
By Greg Bedard
NBCSports.com contributor
updated 6:56 p.m. ET Sept. 29, 2012
Greg Bedard
As NFC East rivals, the Giants and Eagles are certainly very familiar with each other.
But this Eagles team is much different than the version the Giants saw last season in Week 3 (Giants won 29-16) and Week 11 (Eagles won 17-10).
In the first meeting last season, the Eagles? defense under new coordinator Juan Castillo was very much in flux. The struggles on that side contributed to Philadelphia starting the season 1-4 and then 4-8. In the second meeting, Eagles quarterback Michael Vick was injured and Vince Young led Philadelphia to victory.
So while the teams know each other well, the Giants have more to adjust to this time around. The Eagles know what they?re getting from the Giants. The personnel may have changed a little bit, but with Kevin Gilbride and Perry Fewell directing the offense and defense, respectively, Philadelphia can gameplan with a little more certainty.
But, as always, the matchups will tell the tale in the Sunday Night Football game. After going over the tape, here are the five most crucial aspects of the matchups between the Eagles and Giants:
Limiting Victor Cruz No one knew who Giants receiver Victor Cruz was in the first two weeks of the 2011 season when he had two catches for 17 yards. Cruz set the stage for his breakout season in Week 3 against the Eagles when he had three catches for 110 yards and two touchdowns, including an electrifying 74-yard score. In the Week 11 matchup, Cruz was even better with six catches for 128 yards and a touchdown.
The Eagles had problems against Cruz because the Giants like to move him around a lot. That was also a problem for Philadelphia last week against the Cardinals when Larry Fitzgerald had nine catches for 114 yards and a touchdown. Cruz and Fitzgerald are different players physically, but their teams use them in similar fashion. The Eagles are simply going to have to figure out a better way to do with those types of players.
When Cruz is lined up on the left side, cornerback Nnamdi Asomugha can handle him. It?s elsewhere that is the problem. The best option would likely be to matchup Dominique Rodgers-Cromartie, who is physical and athletic, against Cruz. Rookie nickel back Brandon Boykin would seem to be overmatched against Cruz. You can bet Gilbride will be designing ways to get Boykin into coverage against Cruz, but the Eagles will need to have answer for it. Expect Philadelphia to use some sort of bracket coverage against Cruz with help from linebackers or a safety.
Slowing the Eagles' pass rush Philadelphia is really starting to click with four-man rush, which stars Jason Babin (2.5 sacks) at left end, and Trent Cole (1.5 sacks) on the right side. The Eagles use a heavy line rotation, so backups Darryl Tapp and Brandon Graham will also get their snaps. The Giants have to feel good that left tackle Williams Beatty has returned to the lineup and played well. That has allowed Sean Locklear to go back to the right side, where his skills fit better. The Giants use a lot of sets that involved multiple tight ends and running backs, so they will be asked to help on the edges against the ends.
Where the Eagles might have an edge is up the middle. Starting defensive tackles Derek Landri and Cullen Jenkins are very disruptive and are more physical than the interior Giants line of left guard Kevin Boothe, center David Baas and right guard Chris Snee. Fletcher Cox and Cedric Thornton are the rotation guys at tackle for the Eagles, who run a nine-man line rotation to keep players fresh.
Giants' secondary on the spot Giants safety Antrel Rolle (knee laceration) isn?t a sure thing to play, but it?s likely he?s out there. But with right cornerbacks Jayron Hosley and Michael Coe dealing with hamstring injuries, that means third-stringer Prince Amukamara will be starting for the Giants. He has yet to live up to his 2011 first-round draft status, so expect the Eagles to go after him. Amukamara played well in the Thursday night blowout victory over the Panthers, but the Eagles are more dangerous with receivers DeSean Jackson and Jeremy Maclin.
Giants DE Jason Pierre-Paul vs. Eagles LT Demetress Bell Everyone knows how lethal the Giants? pass rush is, and that should certainly continue against an Eagles line that allows a ton of pressure. Vick brings on some of the issues himself with indecisiveness and holding onto to the ball too long, but the Eagles will need to play well up front to win.
Bell has the toughest job against exquisite end Jason Pierre-Paul, who has 1.5 sacks and about a dozen other quarterback pressure so far this season. This is a matchup where not having starting left tackle Jason Peters (ruptured Achilles) really hurts. The Eagles are going to have to help Bell against Pierre-Paul, or Vick is going to running the entire game.
Eagles RB LeSean McCoy vs. Giants DE Osi Umenyiora These two have had a well-publicized battle of verbal and Twitter shots for some time, so there?s a little extra fuel on the fire. The latest installment of this feud came last week when McCoy called Umenyiora ?a ballerina in a Giants uniform? during an ESPN interview. Umenyiora has called McCoy ?Lady Gaga? in the past, and even wished him a happy Mother?s Day.
Most of it is in good fun among rivals, but the Giants know they have to be serious about stopping McCoy, last season?s All-Pro running back, if they want to win. He has rushed for at least 100 yards in three of his six career games against the Giants. To limit a shifty, cut-back runner like McCoy, the Giants are going to have to be sound in their gaps and run fits, and not just on the defensive line. Linebackers Mathias Kiwanuka (strong side), Chase Blackburn (middle) and Michael Boley (weak) will need to be disciplined.
Complicating things are the motions with Jackson, and the play-action bootlegs the Eagles like to use with Vick. If the linebackers are fooled by any of the play fakes, that will leave McCoy amble room to gash the Giants on the backside.?
Greg Bedard is a contributor to NBCSports.com and the NFL writer for the Boston Globe. Follow him on Twitter @GregABedard.
? 2012 NBC Sports.com? Reprints
advertisement
More newsKevin C. Cox / Getty Images
Ryan rallies Falcons
Matt Bryant kicked a 40-yard field goal with 5 seconds remaining and the Atlanta Falcons remained unbeaten, rallying past the Carolina Panthers 30-28 on Sunday.
49ers run all over Jets 34-0
Carlos Rogers returned a fumble 51 yards for a touchdown, and the San Francisco 49ers ran for more than 200 yards to rout the New York Jets 34-0 on Sunday.
ARLINGTON, Texas (AP) - Angels center fielder Mike Trout has become the first major league rookie ever with 30 home runs and 40 stolen bases.
Trout hit his 30th homer Sunday, a two-out solo shot in the seventh inning at Texas off Yu Darvish.
The 21-year-old Trout had a leadoff walk to start the game, then quickly got his 48th stolen base.
Only two players in the majors have ever had 30 homers and 50 stolen bases - Eric Davis in 1987 and Barry Bonds in 1990.
The Angels have four games left in the regular season, including the second game of Sunday's day-night doubleheader against the AL West-leading Rangers.
Trout homered in the seventh inning Sunday
? 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Take-Two and 2K Sports are finally making good on their promise to bring their reining, undisputed top NBA franchise to China. NBA 2K Online will debut in the region on October 24th.
In a partnership with gaming giant Tencent, NBA 2K Online will hope to capitalize on the thriving PC market, which fuels tons of MMORPG titles and online franchises.
If everyone plays their cards right, NBA 2K Online could become an extremely profitable venture for both groups.
2K China?s official English website?for the game hasn?t been updated in a while, but?NBA 2K Online is a confirmed free-to-play title that will feature plenty of social media-inclined modes.
Tencent (and by extension, 2K China) have come under a little bit of scrutiny for their marketing and advertising campaign, which features scantily-clad Chinese models as cheerleaders, rather than actual basketball players.
Tencent Holdings Limited is covering a lot of ground in Chinese gaming with this deal, also partnering with Activision for Call of Duty Online and acquiring Riot Games. They also bought a piece of Epic Games recently, buying an unannounced minority portion of the company?s stock.
LONDON (Reuters) - A new and potentially fatal virus from the same family as SARS which was discovered in a patient in London last week appears not to spread easily from person to person, the World Health Organization (WHO) said on Friday.
In an update on the virus, which has so far killed a Saudi man and made a patient from Qatar critically ill, the United Nations health agency said it was working with international partners to understand the public health risk better.
"From the information available thus far, it appears that the novel coronavirus cannot be easily transmitted from person to person," it said in a statement.
The WHO put out a global alert on Sunday saying a new virus had infected a 49-year-old Qatari who had recently travelled to Saudi Arabia, where another man with the same virus had died.
The Qatari was described as critically ill on Tuesday and is being treated in a London hospital. No new confirmed cases of infection with the virus have since been reported, the WHO said.
The new virus shares some of the symptoms of SARS, or Severe Acute Respiratory Syndrome, another coronavirus, which emerged in China in 2002 and killed around a tenth of the 8,000 people it infected worldwide.
Both patients who have so far been confirmed with the new virus suffered kidney failure.
SEVERITY
"Given the severity of the two laboratory confirmed cases, WHO is continuing to monitor the situation in order to provide the appropriate response, expertise and support to its member states," the WHO statement said.
Scientists at the European Centre for Disease Prevention and Control (ECDC), which monitors disease in the European Union, said initial virology results and the separation in time of the only two confirmed cases suggest the infection may have developed from animals. Such diseases are known as zoonoses.
"(It) is quite probably of zoonotic origin and different in behaviour from SARS," the scientists wrote in a "rapid communication" study in the online journal Eurosurveillance.
Asked about transmission and the possibility of animal to human spread, WHO spokesman Glenn Thomas said investigations were continuing.
"But from the evidence we have, and given that there are only two cases confirmed so far and there was a distance and time distance between the two cases, (the) assumption is that it isn't easily transferable person to person," he told reporters.
The WHO's clinical guidance to its 194 member states says health workers should be alert to anyone with acute respiratory syndrome and requiring hospitalization who had been in the Middle East where the virus was found or in contact with a suspected or confirmed case within the previous 10 days.
The U.N. agency has not recommended any travel restrictions in connection with the new virus, but said it was working closely with Saudi authorities on health measures for Muslims making the haj pilgrimage to Mecca.
Health experts said rapid progress has already been made in figuring out the nature and genetic makeup of the new coronavirus, and in coming up with tests.
"We are developing with our partners sensitive and specific diagnostic assays and these should be available in the next few days," Thomas told a briefing at WHO headquarters in Geneva.
"If any national authority is concerned about a patient who is under investigation, if they want to contact us, we can put them in touch with these laboratories and provide initial tests for any cases which are suspicious," he added.
(Additional reporting by Stephanie Nebehay in Geneva; Editing by David Stamp and Giles Elgood)
Vice President Joe Biden greets supporters during a campaign event at the Century Village Clubhouse in Boca Raton, Fla., Friday, Sept. 28, 2012. (AP Photo/Terry Renna)
Vice President Joe Biden greets supporters during a campaign event at the Century Village Clubhouse in Boca Raton, Fla., Friday, Sept. 28, 2012. (AP Photo/Terry Renna)
FORT MYERS, Fla. (AP) ? Vice President Joe Biden says that he and President Barack Obama had been on the job less than a week when a top economic adviser told them the country was facing a trillion-dollar budget deficit.
Biden says that Obama replied, "But I haven't done anything yet."
Biden blames the deficit on the previous Bush administration, adding that it "put two wars on a credit card" and gave tax cuts to the wealthy after inheriting a balanced budget and revenue surplus from the Clinton administration.
Biden hammered GOP presidential candidate Mitt Romney for comments on a leaked video in which Romney describes 47 percent of Americans as paying no federal income tax and believing "they are victims."
Biden made his remarks Saturday to more than 2,000 people in Fort Myers, Fla.
This file picture taken on Oct. 10, 2006 shows Pope Benedict XVI with his then butler Paolo Gabriele (right) in St Peter's Square, Rome.
By Claudio Lavanga, NBC News
VATICAN CITY -?One of the most sensational trials to be held in the Vatican for centuries got under way Saturday with Benedict XVI?s former butler, Paolo Gabriele, standing accused of leaking confidential documents from the pope?s apartments to the media.
Some of the documents suggested the existence of a web of corruption, nepotism and cronyism linked to the awarding of contracts for the maintenance of the Vatican estate. Others showed signs of widespread infighting among cardinals.?
Gabriele could be given a sentence of up to four years in prison if found guilty of ?aggravated theft.? ?
The Vatican State does not actually have a prison -- only security cells for temporary confinement. But, according to a 1929 agreement with ?neighboring? Italy, anyone sentenced in the Vatican will serve their time there.
Vatican says the 'butler did it,' orders trial
The public trial is taking place in the Vatican?s tribunal, a small courtroom in a 19th century building in Piazza San Marta.
Gabiele was in the courtroom Saturday, dressed in a gray suit. Journalists in the small pool allowed in the room said he looked tense but laughed with his lawyer at one stage. He did not betray any other emotions.
The judges said it would be a short trial, and could be over in as little as four hearings, meaning that a verdict could be reached by the end of next week.
At the hearing, which only lasted two hours, it emerged the documents and IT material seized from the butler's house filled 82 boxes, though this does not mean all of it was confidential.?
?Vatileaks,? as the case has become known, is expected to be the biggest trial held by world?s smallest state for centuries.
?Vatican judges usually have to deal with a maximum of 30 crimes per year,? Professor Giovanni Giacobbe, a Vatican legal expert, told journalists Thursday. ?Mostly petty crimes like pickpocketing that are dealt with within a day.?
Pope Benedict's butler, Paolo Gabriele, has been arrested for stealing confidential documents and leaking papal secrets. The Vatican says this is "the beginning of a large investigation." NBC's Michelle Kosinski reports.
The biggest crime to emerge from St. Peter?s Square in recent memory -- the attempted assassination of Pope John Paul II in 1981 -- was tried in an Italian court, while the 1998 killing of a Swiss Guard commander and his wife never went to trial as the Swiss Guard who pulled the trigger turned the gun on himself.
The Vatican?s penal law is based on an Italian code, which dates back to 1889.
Unlike in the United States and other countries, a defendant here is not required to enter a plea, ?like they do in Perry Mason,? Giacobbe joked.
Pope Benedict: 'Sadness in my heart' over butler leak scandal
Defendants are also not asked to take an oath before testifying.
Gabriele, a 46-year-old father of three, has already admitted his role in the conspiracy, and may now pray his confession will lead to a reduced sentence or even a papal pardon.
He was one of the very few people to have access to the pope?s private chambers and was caught red-handed when a stash of secret documents was found in his apartment, along with a cheque of $130,000, a rare 16th century edition of the Aeneid and a gold nugget, all presents sent to the Pope.
He was held for 53 days in a Vatican cell before being put under house arrest.
Gabriele confessed and claimed ?he felt like an agent of the Holy Spirit,? seeking to expose and root out the "evil and corruption" in the Catholic church.?
Author J.K. Rowling during an event to publicize her adult fiction book ?The Casual Vacancy? in London September 27. J.K. Rowling?s first foray into adult fiction was bound to be compared to her wildly successful Harry Potter series, and, while ?The Casual Vacancy? has earned mixed reviews, for some critics the magic has worn off.
Photograph by: PAUL HACKETT , REUTERS
LONDON ? What does the author of the most eagerly awaited book of the year do on publication day?
If you are J.K. Rowling, whose adult fiction debut ?The Casual Vacancy? hit the shelves on Thursday, you watch a movie in your hotel, avoid reading newspaper reviews and later in the evening address 900 people at a question-and-answer session.
The 47-year-old read from her new novel and took questions on death, digital publishing and the Olympics opening ceremony at her first public appearance to promote The Casual Vacancy held at London?s Southbank Centre (southbankcentre.co.uk).
She engaged openly with fans, at one point accepting a gift from a breathless visitor from Spain whom she embraced and kissed on stage, and later personally signed hundreds of copies of her new book.
Asked by moderator Mark Lawson how she had spent her day, she replied: ?I?ve spent most of the day trying to avoid newspapers. I will read reviews, but I don?t like to do it on a day where I?ve got to go out and talk about the book.
?We sat in our hotel and watched ?Men in Black 3?. I?d never seen it. It was very good."
Rowling, who received mixed reviews for her gritty tale about a small English town, added that she probably would read what critics had to say eventually, just as she did with the seventh and final Harry Potter instalment published in 2007.
?With (?Harry Potter and the) Deathly Hallows? I didn?t read any of the reviews at all for ages.
?I kind of felt about Hallows the way I feel about this book. In both cases I felt well, I?ve done the best I can do, the book is what I want it to be, so, I don?t mean it in an arrogant way, that?s it. I?m done. So it doesn?t really matter.
?I did later. It was months later. It takes the heat out of it if you?re not reading them on publication day.?
?SOCIALIST MANIFESTO?
The release of The Casual Vacancy is one of the highlights of the publishing calendar this year, with hefty sales expected for a writer whose Potter series sold 450 million copies and who went on to become the world?s first billionaire author.
Rowling could not resist mentioning one review, however, which she had clearly either read or been told about.
Jan Moir wrote a scathing assessment in the Daily Mail, a newspaper considered the preserve of the middle class which Moir felt Rowling had unfairly lampooned in her book.
Moir described The Casual Vacancy as ?more than 500 pages of relentless socialist manifesto masquerading as literature?, a description Rowling, who was an unemployed single mother living on state benefits when she started writing the Potter books, took as a compliment.
?A 500 page socialist manifesto. I high-fived my husband!? she joked. ?I thought that?s all right. It made me laugh so much. Apart from Men in Black 3 that was the highlight of my day.?
Rowling was asked why death was such a prominent theme throughout her work.
?Death obsesses me. What can I tell you?? she said. ?I can?t really understand why it doesn?t obsess everyone. I think it does really, I?m just maybe a little more out about it.
?It?s made me much less afraid of it,? she added later. ?I think things lose their mystique when you think about them a lot and you consider them a lot.
?I?m frightened of leaving my children. It?s the thing I dislike most about the idea that I will die, but death itself doesn?t frighten me really.?
POTTER MISTAKES
She said she understood why her publishers, Little, Brown Book Group, had imposed strict conditions on allowing journalists to read the book before publication.
?The Internet really has changed everything. It?s the net that?s done it,? she explained, quoting examples of other leading writers who had seen their manuscripts end up online or proofs being auctioned on eBay.
?As a writer that is a horrible, horrible experience.?
On Potter, Rowling admitted she had made mistakes, in particular a mirror belonging to the character Sirius Black in ?Harry Potter and the Order of the Phoenix?, the fifth book.
The ?Marauder?s Map? used by Potter was also problematic.
?Half way through the series I cursed myself for giving Harry the Marauder?s Map, because it was far too useful an object so I had to take it away from him and then give it back to him.
?That?s the trouble. You invent these amazing objects, and then they cause you as much trouble as they solve. So quite a bit of that went on.?
In a separate BBC Radio interview broadcast on Thursday, Rowling said that the world of witches and wizards ?does sometimes tug at me a little bit,? although she had no plans to write anything else Potter-related.
?I?ve always said never say never purely because I liked it and I might want to do it again, but Harry?s stories I am as sure as you can be it is done.?
Rowling added that two books for children ?are pretty well developed? and she knew what her next one for adults would be, although it was ?not very well advanced.?
NEW FAIRFIELD, Conn. -- During what appeared to be an attempted late-night burglary, a man fatally shot a masked teenager in apparent self-defense outside his sister's house and then discovered it was his son, state police said.
Police said 15-year-old Tyler Giuliano was shot at about 1 a.m. on Thursday in New Fairfield, a town just north of Danbury.
The shooter's sister was alone in her house when she believed someone was breaking in. She called her brother, who lives next door, and he grabbed a gun and went outside to investigate, police said.
The father confronted someone wearing a black ski mask and black clothing and then fired his gun when the person went at him with a shiny weapon in his hand, police said.
Father sitting on grass When police officers arrived, the teen was lying in the driveway of the woman's home with gunshot wounds and the father was sitting on the grass. The teen was pronounced dead at the scene, police said.
"All in all it's a tragedy," state police spokesman Lt. J. Paul Vance said.
The Associated Press said teen's father, Jeffrey Giuliano, a fifth-grade teacher in town, had not returned a message seeking comment on what happened.
Read more from NBCConnecticut.com
NBCConnecticut.com spoke to members of the community about what happened.
"The fact that it was a father and son involved in the shooting and the way that it all happened, I think people quite frankly are devastated. This is a teacher who is very loved," one man told the station.
One of Giuliano's students described him as "one of the best teachers I ever had."
Read more U.S. stories from NBC News
The teenager was a student at New Fairfield High School, a short walk from the neighborhood where he was killed.
Superintendent of Schools Alicia Roy sent parents an email about what happened, The News-Times of Danbury reported.
"Our district has experienced a tragedy that has affected us deeply," she wrote, adding that students weren't told of the killing because all the facts weren't clear.
No charges have been filed. State police are investigating. An autopsy on the boy is planned.
The Associated Press contributed to this report.
More content from NBCNews.com:
Follow US News from NBCNews.com on Twitter and Facebook
On Thursday, NASA's Mars Curiosity rover identified what are believed to be rocks moved by water that once flowed on the Red Planet. Curiosity's further exploration is hoped to determine whether Mars was once inhabited by microorganisms.?
By Irene Klotz,?Reuters / September 27, 2012
This image provided by NASA shows a Martian rock outcrop near the landing site of the rover Curiosity thought to be the site of an ancient streambed, next to similar rocks shown on earth.
AP Photo/NASA
Enlarge
NASA's?Mars rover, Curiosity, dispatched to learn if the most Earth-like planet in the solar system was suitable for microbial life, has found clear evidence its landing site was once awash in water, a key ingredient for life, scientists said Thursday.
Click Here for your FREE 30 DAYS of The Christian Science Monitor Weekly Digital Edition
Curiosity, a roving chemistry laboratory the size of a small car, touched down on Aug. 6 inside a giant impact basin near the planet's equator. The primary target for the two-year mission is a three-mile (five-km) -high mound of layered rock rising from the floor of Gale Crater.
Scientists suspect the mound, known as Mount Sharp, is the remains of sediment that once completely filled the crater. Analysis of a slab of rock located between the crater's north rim and the base of Mount Sharp indicate a fast-moving stream of water once flowed there.
Images taken by Curiosity and released on Thursday show rounded stones cemented into the rock, which rises like a piece of jack-hammered sidewalk from the planet's surface.
The stones inside the rock are too big to have been moved by wind, Curiosity scientist?Rebecca Williams, with the Planetary Science Institute in?Tucson,?Arizona, told reporters on a conference call.
"The consensus of the science team is that these are water-transported gravel in a vigorous stream," she said.
The rock is believed to be from the floor of an ancient stream which was once between ankle- and knee-deep.
The analysis is based on telephoto images taken by the rover, which is en route to a patch of land named Glenelg where three different types of rock intersect.
Scientists have not yet decided if the slab of rock warrants a chemical analysis, or if there are better targets for Curiosity to look for the building blocks of life and the minerals to preserve it.
"The question about habitability goes beyond the simple observation of water on Mars," said lead scientist John Grotzinger at the?California Institute of Technology.
"Certainly flowing water is a place where microorganisms could have lived. This particular kind of rock may or may not be a good place to preserve those components that we associate with a habitable environment," he said.
The $2.5 billion?Mars Science Laboratory Curiosity mission?is NASA's first astrobiology mission since the 1970s-era Viking probes.
We'll be seeing more of Honey Boo Boo's family soon.
Here Comes Honey Boo Boo aired its season finale last night on TLC ? which should leave you feeling either disappointed or relieved, depending on which side of the Love It/Loathe It fence you?re on.
For the last few weeks, our national attention has been drawn to the antics of Alana ?Honey Boo Boo? Thompson and her unique family. Jimmy Kimmel even made a joke about the show in the first few minutes of the Emmys broadcast. Meanwhile, Honey Boo Boo and her mother ?Mama June? Shannon have become the hottest reality personalities in town.
So if you think we won?t be hearing about the family for a while now that the show is on hiatus, think again! Here?s what we?ve found out about Alana and her clan in just the last couple of days?
They?ll be home for the holidays. And on our home TVs, too. According to Us Weekly, TLC has ordered more episodes of the hit series, which will feature Honey Boo Boo, Mama June, Sugar Bear, Pumpkin, Chubbs and Chickadee celebrating Halloween, Thanksgiving and Christmas.
Sugar Bear is back home. After an ATV accident, Alana?s dad, Mike ?Sugar Bear? Thompson developed an infection in his leg that landed him in the hospital for nearly two weeks. It was thought that he might need surgery ? and possibly even require amputation. But the infection has cleared up with strong doses of antibiotics, and cameras caught him returning home yesterday.
Little Kaitlyn won?t be getting corrective surgery yet. On last night?s episode, June?s oldest daughter, Anna ?Chickadee? Shannon, gives birth to a baby girl. Viewers also learned that the baby has an unusual birth condition ? two thumbs on her right hand. But contrary to what you may think, the condition isn?t necessarily easy to correct. June recently explained that the extra appendage will be staying for a while. ?The doctor doesn?t want to do anything right now because they don?t know the full function of the other thumb or if they?re connected,? she says. Removing the thumb might cause Kaitlyn to lose function in the rest of her hand. ?They don?t want to make any rash decisions.?
The family is enjoying its fifteen minutes of fame. June bristles at the suggestion that she?s harming Alana and her sisters in any way by doing the show. ?I don?t exploit Alana,? she told RadarOnline. ?I would never exploit my kids. Critics are critics, and everyone has their opinions, but I am not doing anything wrong. It?s always been about fun, and it?s an experience in life they can look back at. We watch the show and wish they put in more stuff!?
They may be getting more money for the show. Holla?! According to an insider source, the family is negotiating a higher salary for a new season, and will probably end up receiving around $8,000 per episode. Still, that?s nowhere near the $30 million the Kardashian family reportedly is receiving for their next three seasons.
They?re not as unusual as you might think. Okay, not everyone tries owning a miniature pig or goes on the kiddie beauty-pageant circuit. But in one aspect, June and her daughters are very much like many of their fellow Georgia families: Nearly 40 percent of families in the state are at risk of health problems related to childhood obesity. A major Georgia pediatric hospital issued a statement: ?[B]ased on the children and families we see at Children?s Healthcare of Atlanta, the truth is that Honey Boo Boo and her family?s health habits may be more of the norm in Georgia than everyone would like to believe.?
Will you be redneckognizing this fun bunch next season?
[Photo: via TLC]
More from Shana:
Miami Nice! Kim and Kourtney Kardashian Hit the Beach
Kate Gosselin on the Emmys, the Kids? Best Day Ever and an ?Exciting? Hint!
Stars Tweet the Emmys!
Wedding Plans, Breakups and Medical Emergencies! This Week in ?Teen Mom? News
Read more of Shana?s writing at Momsperiments.
And don?t miss a post! Follow Shana on Twitter!
Don?t miss the latest from Famecrawler ? like our Facebook page!
MORE ON BABBLE:
7 things Kourtney Kardashian?s daughter should know 25 celebrities who gave birth before turning 25
Mayo Clinic finds way to weed out problem stem cells, making therapy safer Public release date: 27-Sep-2012 [ | E-mail | Share ]
Contact: Jennifer Schutz newsbureau@mayo.edu 507-284-5005 Mayo Clinic
ROCHESTER, Minn. -- Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult tissues to have properties of embryonic stem cells, which have the unlimited capacity to differentiate and grow into any desired types of cells, such as skin, brain, lung and heart cells. However, during the differentiation process, some residual pluripotent or embryonic-like cells may remain and cause them to grow into tumors.
"Pluripotent stem cells show great promise in the field of regenerative medicine; however, the risk of uncontrolled cell growth will continue to prevent their use as a therapeutic treatment," says Timothy Nelson, Ph.D., M.D., lead author on the study, which appears in the October issue of STEM CELLS Translational Medicine.
Using mouse models, Mayo scientists overcame this drawback by pretreated stem cells with a chemotherapeutic agent that selectively damages the DNA of the stem cells, efficiently killing the tumor-forming cells. The contaminated cells died off, and the chemotherapy didn't affect the healthy cells, Dr. Nelson says.
"The goal of creating new therapies is twofold: to improve disease outcome with stem cell-based regenerative medicine while also ensuring safety. This research outlines a strategy to make stem cell therapies safer for our patients while preserving their therapeutic efficacy, thereby removing a barrier to translation of these treatments to the clinic," says co-author Alyson Smith, Ph.D.
Stem cell therapies continue to be refined and improved. Researchers are finding that stem cells may be more versatile than originally thought, which means they may be able to treat a wider variety of diseases, injuries and congenital anomalies. Stem cell therapy is an emerging regenerative strategy being studied at Mayo Clinic.
"By harnessing the potential of regenerative medicine, we'll be able to provide more definitive solutions to patients," says Andre Terzic, M.D., Ph.D., co-author and director of Mayo Clinic's Center for Regenerative Medicine.
###
Other members of the Mayo research team included Clifford Folmes, Ph.D., Katherine Hartjes, Natalie Nelson and Saji Oommen, Ph.D. The research was supported by the Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome, National Institutes of Health New Innovator Award OD007015-01, and a Mayo Clinic Center for Regenerative Medicine accelerated research grant.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and www.mayoclinic.org/news
MULTIMEDIA ALERT: Video resources, including an interview with Dr. Nelson will be available for journalists at the Mayo Clinic News Network.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Mayo Clinic finds way to weed out problem stem cells, making therapy safer Public release date: 27-Sep-2012 [ | E-mail | Share ]
Contact: Jennifer Schutz newsbureau@mayo.edu 507-284-5005 Mayo Clinic
ROCHESTER, Minn. -- Mayo Clinic researchers have found a way to detect and eliminate potentially troublemaking stem cells to make stem cell therapy safer. Induced Pluripotent Stem cells, also known as iPS cells, are bioengineered from adult tissues to have properties of embryonic stem cells, which have the unlimited capacity to differentiate and grow into any desired types of cells, such as skin, brain, lung and heart cells. However, during the differentiation process, some residual pluripotent or embryonic-like cells may remain and cause them to grow into tumors.
"Pluripotent stem cells show great promise in the field of regenerative medicine; however, the risk of uncontrolled cell growth will continue to prevent their use as a therapeutic treatment," says Timothy Nelson, Ph.D., M.D., lead author on the study, which appears in the October issue of STEM CELLS Translational Medicine.
Using mouse models, Mayo scientists overcame this drawback by pretreated stem cells with a chemotherapeutic agent that selectively damages the DNA of the stem cells, efficiently killing the tumor-forming cells. The contaminated cells died off, and the chemotherapy didn't affect the healthy cells, Dr. Nelson says.
"The goal of creating new therapies is twofold: to improve disease outcome with stem cell-based regenerative medicine while also ensuring safety. This research outlines a strategy to make stem cell therapies safer for our patients while preserving their therapeutic efficacy, thereby removing a barrier to translation of these treatments to the clinic," says co-author Alyson Smith, Ph.D.
Stem cell therapies continue to be refined and improved. Researchers are finding that stem cells may be more versatile than originally thought, which means they may be able to treat a wider variety of diseases, injuries and congenital anomalies. Stem cell therapy is an emerging regenerative strategy being studied at Mayo Clinic.
"By harnessing the potential of regenerative medicine, we'll be able to provide more definitive solutions to patients," says Andre Terzic, M.D., Ph.D., co-author and director of Mayo Clinic's Center for Regenerative Medicine.
###
Other members of the Mayo research team included Clifford Folmes, Ph.D., Katherine Hartjes, Natalie Nelson and Saji Oommen, Ph.D. The research was supported by the Todd and Karen Wanek Family Program for Hypoplastic Left Heart Syndrome, National Institutes of Health New Innovator Award OD007015-01, and a Mayo Clinic Center for Regenerative Medicine accelerated research grant.
About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit http://www.mayoclinic.org/about and www.mayoclinic.org/news
MULTIMEDIA ALERT: Video resources, including an interview with Dr. Nelson will be available for journalists at the Mayo Clinic News Network.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
RIYADH, Saudi Arabia (AP) ? A Saudi security official says two people were killed during a raid to arrest a wanted man in an oil-rich region that's been the scene of unrest by the country's Shiite minority.
The clash in the Qatif area comes as Saudi authorities try to root out suspected leaders of the protesters. Shiites claim they face discrimination and other abuses at the hands of the Sunni monarchy.
The official Saudi Press Agency reported on Thursday that the wanted man and a fellow gunman were killed during a gun battle. The report, citing an unnamed security official, says agents had traced them to a house on Wednesday.
More than a dozen people have been killed in clashes since late last year in Qatif, the kingdom's main oil export hub.
'Roger was supposed to propose to me first. I'm a little angry,' Ronnie Ortiz-Margo and 'Jersey Shore' housemates joke with MTV News. By Christina Garibaldi
JWoww and Roger Mathews in In Touch magazine Photo: In Touch
ScienceDaily (Sep. 25, 2012) ? Squamous cell carcinoma (SCC) is diagnosed in about 700,000 people in the United States every year. Commonly contributing to SCC is a protein called DNp63a -- it goes abnormally high and the ability of a patient's body to kill cancer cells goes abnormally low. In many cases of SCC, it's just that simple. And science thought the function of DNp63a was simple, as well: the tumor suppressor gene p53 is responsible for recognizing and killing cancer cells, and in SCC, it's usually inactivated. It looked like high DNp63a repressed p53, made SCC.
A University of Colorado Cancer Center study published September 26 in the journal Genes & Development throws the accepted role of DNp63a on its ear. Though high DNp63a and low p53 activity are correlated in SCC, there's no causation -- DNp63a doesn't affect p53. Instead, DNp63a employs "epigenetics" to keep cancer cells alive.
"This is a potent oncogene whose mechanism we thought we knew. But basically in this paper we demolish the accepted model. DNp63a doesn't work through p53 -- it operates through epigenetic silencing of anti-proliferative genes," says the study's senior author, Joaquin M. Espinosa, PhD, investigator at the CU Cancer Center and associate professor in the Department of Molecular, Cellular and Developmental Biology at CU Boulder.
Genes are blueprints that code for proteins and these proteins in turn drive most things that happen in the body, both good and bad. But between genes and their protein products is the layer of epigenetics -- genes may be expressed differently depending on the heritable, epigenetic features that turn them on and off. In the case of DNp63a, it employs a protein partner called H2A.Z, which in volume effectively buries anti-proliferative genes in silt, rendering them unable to go about their anti-cancer duties.
"Independently of p53, DNp63a is shutting down genes that stop cell division -- shutting down anti-proliferative genes so that cells can keep dividing and dividing and dividing," Espinosa says.
Now that the function of DNp63a is known, Espinosa is looking inside the chain of events for a breakable link.
"DNp63a itself isn't druggable," he says, "but the enzymes that partner with DNp63a for epigenetic silencing are."
With a mechanism in hand, Espinosa and colleagues can now explore in animal models the possible effects of breaking the DNp63a mechanism. Drug away an essential enzyme and DNp63a may lose its ability to cause cancer.
Share this story on Facebook, Twitter, and Google:
Other social bookmarking and sharing tools:
Story Source:
The above story is reprinted from materials provided by University of Colorado Denver. The original article was written by Garth Sundem.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
Corrie L. Gallant-Behm, Matthew R. Ramsey, Claire L. Bensard, Ignacio Nojek, Jack Tran, Minghua Liu, Leif W. Ellisen, and Joaqu?n M. Espinosa. ?Np63? represses anti-proliferative genes via H2A.Z deposition. Genes Dev., September 26, 2012 DOI: 10.1101/gad.198069.112
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Researchers have now proposed an experimental design for a 'space-time crystal' that would be able to keep time forever.
By Clara Moskowitz,?LiveScience Senior Writer / September 25, 2012
Scientists have proposed a way to build a clock that will keep perfect time forever.
Berkeley Lab
Enlarge
The idea for an eternal clock that would continue to keep time even after the universe ceased to exist has intrigued physicists. However, no one has figured out how one might be built, until now.
Click Here for your FREE 30 DAYS of The Christian Science Monitor Weekly Digital Edition
Researchers have now proposed an experimental design for a "space-time crystal" that would be able to keep time forever. This four-dimensional crystal would be similar to conventional?3D crystals, which are structures, like snowflakes and diamonds, whose atoms are arranged in repeating patterns. Whereas a diamond has a periodic structure in three dimensions, the space-time crystal would be periodic in time as well as space.
The idea of a 4D space-time crystal was first proposed earlier this year by MIT physicist Frank Wilczek, though the concept was purely theoretical. Now a team of researchers led by Xiang Zhang of California's Lawrence Berkeley National Laboratory has conceived of how to make one a reality.
"The idea of creating a crystal with dimensions higher than that of conventional 3D crystals is an important conceptualbreakthrough in physics, and it is very exciting for us to be the first to devise a way to realize a space-time crystal," Berkeley Lab physicist Tongcang Li, a member of the research group, said in a statement. [Twisted Physics: 7 Mind-Blowing Findings]
Zhang and his colleagues suggest that a space-time crystal could be constructed using an electric field to trap charged atoms (called ions), and taking advantage of the natural repulsion between two like-charged particles (positive and positive, or negative and negative), which is called Coulomb repulsion.
"The electric field of the ion trap holds charged particles in place and Coulomb repulsion causes them to spontaneously form a spatial ring crystal," Zhang said. "Under the application of a weak static magnetic field, this ring-shaped ion crystal will begin a rotation that will never stop. The persistent rotation of trapped ions produces temporal order, leading to the formation of a space-time crystal at the lowest quantum energy state."
In other words, the scientists would aim to create a ring of charged particles, with the resulting electromagnetic forces causing the structure to rotate perpetually. At its lowest quantum-energy state, also known as its ground state, the system has no disorder, or entropy, and there is no way for its entropy to increase over time. Thus, the crystal's?temporal structure and timekeeping ability would continue even after the universe reached a state of "heat death," also known as thermodynamic equilibrium, when it had devolved into entropy.
The researchers describe their idea in a paper published recently in the journal Physical Review Letters.
Follow LiveScience on Twitter?@livescience. We're also on?Facebook?&?Google+.
![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 27-Sep-2012
Share ] 